VERMODJE – Testover E

Description

An injectable substance with a delayed release rate, Testosterone Enanthate is an esterified form of the hormone. The functional group of the Enanthate ester linked to the Testosterone molecule allows for this gradual release.

Therapeutic indication

In males, Testosterone Enanthate is recommended as a replacement treatment for problems when there is insufficient or no endogenous testosterone. Some of the conditions that are treated include: 1) primary hypogonadism, which is defined as testicular failure caused by cryptorchidism, bilateral torsion, orchitis, vanishing testis syndrome, or orchidectomy; 2) hypogonadotropic hypogonadism, which is caused by an idiopathic gonadotropin or luteinizing hormone-releasing hormone deficiency or due to a pituitary-hypothalamic injury from tumour.

Why choose Testosterone Enanthate over conventional medicine?

Within 24 hours of treatment, Testosterone Enanthate and other ester derivatives of testosterone cause a 400% rise from baseline in blood testosterone levels. After the initial injection, these androgen levels are high for 3 to 5 days. 5 Serum dihydrotestosterone, PSA, HDL, FSH, and estradiol are all significantly decreased when testosterone enanthate is administered continuously. Even 14 days after the end of the medication, dihydrotestosterone and FSH levels can still be lowered. The presence of testosterone enanthate has no effect on a person’s mood or sexual activity.

Pharmacological actions

Activation of the androgen receptor (directly or through DHT) and conversion to estradiol and activation of specific oestrogen receptors are the two major ways that testosterone affects humans and other animals. The cytoplasm of target tissue cells receives free testosterone (T), which is then either converted to 5-dihydrotestosterone (DHT) by the cytoplasmic enzyme 5-reductase or can bind to the androgen receptor. DHT has around 2.5 times the androgenic potency of T because it attaches to the same androgen receptor much more firmly than T does. The structural transformation of the T-receptor or DHT-receptor complex enables it to go into the cell nucleus and attach specifically to certain nucleotide sequences of the chromosomal DNA.

Usage Directions

Pellet: 150-450 mg SC every 3-6 months; 150 mg of pellet approximately equivalent to 25 mg of testosterone propionate weekly

Side effects

• Increased hemoglobin
• Blood prolactin increased
• Upper respiratory tract infection
• Hematocrit increased